Select scientific reports AND RESEARCH DEVELOPMENTS
Researchers identify way to block alphavirus infection
by Washington University in St. Louis
From Medical Xpress.com, 11/27/23
Read more at:
medicalxpress.com/news/2023-11-block-alphavirus-infection.html
by Washington University in St. Louis
From Medical Xpress.com, 11/27/23
Read more at:
medicalxpress.com/news/2023-11-block-alphavirus-infection.html
Rituximab Shows Promise in Reducing Relapse Rates in Autoimmune Encephalitis
From Neurology Advisor, 11/15/23, Author Hibah Khaja, PharmD
Read more at:
www.neurologyadvisor.com/topics/general-neurology/rituximab-relapse-rates-autoimmune-encephalitis/
From Neurology Advisor, 11/15/23, Author Hibah Khaja, PharmD
Read more at:
www.neurologyadvisor.com/topics/general-neurology/rituximab-relapse-rates-autoimmune-encephalitis/
A Novel Cell Therapy Targets Autoimmune Brain Inflammation
From InsidePrecisionMedicine.com, 11/6/23
Read more at:
www.insideprecisionmedicine.com/topics/precision-medicine/novel-cell-therapy-targets-autoimmune-encephalitis/
From InsidePrecisionMedicine.com, 11/6/23
Read more at:
www.insideprecisionmedicine.com/topics/precision-medicine/novel-cell-therapy-targets-autoimmune-encephalitis/
Researchers find new approach for treating autoimmune brain inflammation
From Economic Times Health World, 11/4/23
The team has engineered specialized CAAR-T cells, designed for injection into pa ..
Read more at:
https://health.economictimes.indiatimes.com/news/industry/researchers-find-new-approach-for-treating-autoimmune-brain-inflammation/104961157
From Economic Times Health World, 11/4/23
The team has engineered specialized CAAR-T cells, designed for injection into pa ..
Read more at:
https://health.economictimes.indiatimes.com/news/industry/researchers-find-new-approach-for-treating-autoimmune-brain-inflammation/104961157
Fatigue in Survivors of Autoimmune Encephalitis
Luisa A. Diaz-Arias, Anusha Kierty Yeshokumar, Brittany Glassberg, James F. Sumowski, Ava Easton, John C. Probasco, Arun Venkatesan
This study demonstrates the high impact of fatigue on the quality of life in a broad population of individuals affected by AE. Notably, neither the mRS nor the CASE scale adequately capture fatigue as an outcome because many patients with good mRS or CASE scores at study enrollment reported high levels of fatigue impact. Moreover, mRS scores at hospital discharge did not predict subsequent development of fatigue. Thus, fatigue must be directly ascertained, given its significant impact on the quality of life and the fact that it is a potentially treatable condition.
https://nn.neurology.org/content/8/6/e1064
Luisa A. Diaz-Arias, Anusha Kierty Yeshokumar, Brittany Glassberg, James F. Sumowski, Ava Easton, John C. Probasco, Arun Venkatesan
This study demonstrates the high impact of fatigue on the quality of life in a broad population of individuals affected by AE. Notably, neither the mRS nor the CASE scale adequately capture fatigue as an outcome because many patients with good mRS or CASE scores at study enrollment reported high levels of fatigue impact. Moreover, mRS scores at hospital discharge did not predict subsequent development of fatigue. Thus, fatigue must be directly ascertained, given its significant impact on the quality of life and the fact that it is a potentially treatable condition.
https://nn.neurology.org/content/8/6/e1064
Herpes simplex virus infection presenting as stroke-like symptoms with atypical MRI findings
Camilla N Clark, Nader Khandanpour, Anthony C Pereria
A previously independent 63-year-old women with obesity, obstructive sleep apnoea, type 2 diabetes, and hypercholesterolaemia presented to our stroke team on July 25, 2017, with sudden-onset receptive and expressive dysphasia and right-sided neglect. Her symptoms were managed with antiplatelets. 5 days earlier, she had fallen and sustained an undisplaced fracture of the right humerus. Subsequently, she had intermittent confusion (eg, she was unable to recall her daughter’s name and had placed her mobile phone in boiling water). Low attenuation mimicking acute infarction was visible, on an unenhanced CT brain scan, in the left insular cortex. She progressed rapidly, developing pneumonia, heart failure, and seizures.
www.thelancet.com/journals/laninf/article/PIIS1473-3099(19)30308-1/fulltext
Clinical Epidemiology, Risk Factors, and Outcomes of Encephalitis in Older Adults
Michael A Hansen, MD, Mohammed S Samannodi, MD, Rodrigo Lopez Castelblanco, MD, Rodrigo Hasbun, MD, MPH
Background: Encephalitis is associated with significant morbidity and mortality with unknown etiologies in the majority of patients. Large prognostic studies evaluating elderly patients are currently lacking.
Methods: Retrospective cohort of encephalitis cases in 19 hospitals from New Orleans, Louisiana and Houston, Texas between the years 2000 and 2017.
Conclusion: Encephalitis remains with adverse clinical outcomes and unknown etiologies in the majority of patients in the molecular diagnostic era. Independent prognostic factors include age >65 years, fever, GCS <13 and seizures.
https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciz635/5531017?redirectedFrom=fulltext
A Systematic Review of the Natural Virome of Anopheles Mosquitoes
Ferdinand Nanfack Minkeu and Kenneth D. Vernick
Anopheles mosquitoes are vectors of human malaria, but they also harbor viruses, collectively termed the virome. The Anopheles virome is relatively poorly studied, and the number and function of viruses are unknown. Only the o’nyong-nyong arbovirus (ONNV) is known to be consistently transmitted to vertebrates by Anopheles mosquitoes.
In addition to ONNV, other viruses with potential to cause febrile disease if transmitted to humans or other vertebrates have been isolated from Anopheles, including Nyando virus [18,19], Batai virus [20], Japanese encephalitis virus [21], Myxoma virus [22], and West Nile virus [23].
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977215
Subacute Sclerosing Panencephalitis: The Devastating Measles Complication That Might Be More Common Than Previously Estimated.
Wendorf KA, Winter K, Zipprich J, Schechter R, Hacker JK, Preas C, Cherry JD, Glaser C, Harriman K.
BACKGROUND: Subacute sclerosing panencephalitis (SSPE) is a fatal complication of measles. We reviewed California cases from 1998-2015 to understand risk factors for SPPE and estimate incidence.
https://www.ncbi.nlm.nih.gov/pubmed/28387784
Systematic review of rehabilitation intervention outcomes of adult and paediatric patients with infectious encephalitis
Shanice Christie, Vincy Chan, Tatyana Mollayeva, and Angela Colantonio
Objective Although a range of rehabilitation interventions have been applied to restore function after infectious encephalitis, there is a lack of literature summarising the benefits of these interventions. This systematic review aims to synthesise current scientific knowledge on outcome measures following rehabilitative interventions among children and adults with infectious encephalitis, with a specific focus on the influence of the age, sex, baseline status and intervention type.
Search strategy Five scholarly databases (MEDLINE, Embase, PsycINFO, CINAHL and Cochrane Central Register of Controlled Trials), three sources of grey literature (Google, Google Scholar and Grey Matters) and reference lists of included publications were systematically searched. Literature published before 15 December 2017 and focused on patients with infectious encephalitis in any rehabilitation setting were included.
https://bmjopen.bmj.com/content/8/5/e015928
Incidence, Risk Factors and Outcomes Among Children With Acute Flaccid Myelitis:
A Population-based Cohort Study in a California Health Network Between 2011 and 2016
Kane MS, Sonne C, Zhu S, Malhotra A, Van Haren K, Messacar K, Glaser CA
BACKGROUND: Acute flaccid myelitis (AFM) is defined as an acute onset of limb weakness with longitudinal spinal gray matter lesions. Reporting bias and misdiagnosis confound epidemiologic studies of AFM. We mitigated these confounders by using a large data set to assess AFM incidence, risk factors and outcomes in a fixed population.
Incidence, Risk Factors and Outcomes Among Children with AFM
https://www.ncbi.nlm.nih.gov/pubmed/30985511
Camilla N Clark, Nader Khandanpour, Anthony C Pereria
A previously independent 63-year-old women with obesity, obstructive sleep apnoea, type 2 diabetes, and hypercholesterolaemia presented to our stroke team on July 25, 2017, with sudden-onset receptive and expressive dysphasia and right-sided neglect. Her symptoms were managed with antiplatelets. 5 days earlier, she had fallen and sustained an undisplaced fracture of the right humerus. Subsequently, she had intermittent confusion (eg, she was unable to recall her daughter’s name and had placed her mobile phone in boiling water). Low attenuation mimicking acute infarction was visible, on an unenhanced CT brain scan, in the left insular cortex. She progressed rapidly, developing pneumonia, heart failure, and seizures.
www.thelancet.com/journals/laninf/article/PIIS1473-3099(19)30308-1/fulltext
Clinical Epidemiology, Risk Factors, and Outcomes of Encephalitis in Older Adults
Michael A Hansen, MD, Mohammed S Samannodi, MD, Rodrigo Lopez Castelblanco, MD, Rodrigo Hasbun, MD, MPH
Background: Encephalitis is associated with significant morbidity and mortality with unknown etiologies in the majority of patients. Large prognostic studies evaluating elderly patients are currently lacking.
Methods: Retrospective cohort of encephalitis cases in 19 hospitals from New Orleans, Louisiana and Houston, Texas between the years 2000 and 2017.
Conclusion: Encephalitis remains with adverse clinical outcomes and unknown etiologies in the majority of patients in the molecular diagnostic era. Independent prognostic factors include age >65 years, fever, GCS <13 and seizures.
https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciz635/5531017?redirectedFrom=fulltext
A Systematic Review of the Natural Virome of Anopheles Mosquitoes
Ferdinand Nanfack Minkeu and Kenneth D. Vernick
Anopheles mosquitoes are vectors of human malaria, but they also harbor viruses, collectively termed the virome. The Anopheles virome is relatively poorly studied, and the number and function of viruses are unknown. Only the o’nyong-nyong arbovirus (ONNV) is known to be consistently transmitted to vertebrates by Anopheles mosquitoes.
In addition to ONNV, other viruses with potential to cause febrile disease if transmitted to humans or other vertebrates have been isolated from Anopheles, including Nyando virus [18,19], Batai virus [20], Japanese encephalitis virus [21], Myxoma virus [22], and West Nile virus [23].
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977215
Subacute Sclerosing Panencephalitis: The Devastating Measles Complication That Might Be More Common Than Previously Estimated.
Wendorf KA, Winter K, Zipprich J, Schechter R, Hacker JK, Preas C, Cherry JD, Glaser C, Harriman K.
BACKGROUND: Subacute sclerosing panencephalitis (SSPE) is a fatal complication of measles. We reviewed California cases from 1998-2015 to understand risk factors for SPPE and estimate incidence.
https://www.ncbi.nlm.nih.gov/pubmed/28387784
Systematic review of rehabilitation intervention outcomes of adult and paediatric patients with infectious encephalitis
Shanice Christie, Vincy Chan, Tatyana Mollayeva, and Angela Colantonio
Objective Although a range of rehabilitation interventions have been applied to restore function after infectious encephalitis, there is a lack of literature summarising the benefits of these interventions. This systematic review aims to synthesise current scientific knowledge on outcome measures following rehabilitative interventions among children and adults with infectious encephalitis, with a specific focus on the influence of the age, sex, baseline status and intervention type.
Search strategy Five scholarly databases (MEDLINE, Embase, PsycINFO, CINAHL and Cochrane Central Register of Controlled Trials), three sources of grey literature (Google, Google Scholar and Grey Matters) and reference lists of included publications were systematically searched. Literature published before 15 December 2017 and focused on patients with infectious encephalitis in any rehabilitation setting were included.
https://bmjopen.bmj.com/content/8/5/e015928
Incidence, Risk Factors and Outcomes Among Children With Acute Flaccid Myelitis:
A Population-based Cohort Study in a California Health Network Between 2011 and 2016
Kane MS, Sonne C, Zhu S, Malhotra A, Van Haren K, Messacar K, Glaser CA
BACKGROUND: Acute flaccid myelitis (AFM) is defined as an acute onset of limb weakness with longitudinal spinal gray matter lesions. Reporting bias and misdiagnosis confound epidemiologic studies of AFM. We mitigated these confounders by using a large data set to assess AFM incidence, risk factors and outcomes in a fixed population.
Incidence, Risk Factors and Outcomes Among Children with AFM
https://www.ncbi.nlm.nih.gov/pubmed/30985511